Is There a Link between Ibuprofen and Male Infertility?
A recent study published in the Proceedings of the National Academy of Sciences journal may have found a link between regular ibuprofen use and male infertility. The research team studied a sample of 31 male volunteers between the ages of 18 and 35. About half the men were given a daily dosage of 600 milligrams of ibuprofen twice daily – the maximum limit as directed by the labels of generic ibuprofen products – and the remaining men were given a placebo.
After 14 days, the luteinizing hormones – hormones secreted by the pituitary gland that stimulate the production of testosterone – of the men who were taking the ibuprofen became coordinated with the level of ibuprofen in their bloodstream. Simultaneously, their ratio of testosterone to luteinizing hormones decreased, which can be a sign of reduced fertility in men. Because of this hormonal imbalance, many of the men who were taking the ibuprofen developed hypogonadism, which is a condition associated with impaired fertility, depression, and an increased risk of cardiovascular events like heart failure and stroke. However, the researchers in charge of the study say these symptoms are reversible.
Ibuprofen belongs to a class of drugs called nonsteroidal anti-inflammatory drugs (NSAIDs) and is also sold under the brand names Advil and Motrin. NSAIDs are typically used to treat minor pain and reduce fever. The National Institute of Health says that people who regularly take NSAIDs could have a higher risk of heart attack or stroke than those who don’t. The drug can also cause ulcers and bleeding the stomach or intestines if taken at very high doses or for an extended period. Even before the study, it was already known that ibuprofen is an anti-androgenic drug, which means that it disrupts the production of male hormones.
Impaired fertility is a problem everywhere, and it can cause a massive amount of emotional strain on couples who are attempting pregnancy. The best way to be sure about your fertility is to visit a trusted infertility clinic. IVF Phoenix is more than just your average infertility clinic. They are a team of dedicated specialists who have a passion for helping couples realize their dream of starting a family. IVF Phoenix has helped people with infertility and reproductive challenges for over 20 years. While this was a small study and there are, of course, many more questions to be answered about the effects of ibuprofen on male fertility, it’s still important to know what’s being studied in the scientific community so that you can make informed decisions about your life.